Difloderm Cream (10g)

Difloderm Cream is a topical antifungal and anti-inflammatory formulation used to treat fungal skin infections accompanied by severe itching, redness, and swelling.

PKR 185.00

You save: PKR 0

Quantity:

SKU: DIFLODERM_CREAM_10G

Category: Creams Ointments & Gels

Difloderm Cream is a synergistic topical combination consisting of an imidazole antifungal and a potent corticosteroid designed to treat inflamed cutaneous mycoses. **Isoconazole Nitrate** exerts its broad-spectrum antifungal activity by inhibiting the lanosterol 14-alpha-demethylase enzyme, disrupting the biosynthesis of ergosterol—an essential structural component of fungal cell membranes—which leads to increased membrane permeability and cell death. Simultaneously, **Diflucortolone Valerate** is a glucocorticoid that suppresses inflammatory cascades by inhibiting phospholipase A2, thereby reducing the production of arachidonic acid derivatives like prostaglandins and leukotrienes. This combined pharmacological approach rapidly controls both the underlying fungal pathogen and the associated dermatological tissue inflammation.

Purpose

It is indicated for the initial or intermediary treatment of superficial fungal infections of the skin (such as dermatomycoses, tinea pedis, tinea cruris, and candidiasis) where eczematous or highly inflammatory symptoms are prominent.

Ingredients

Isoconazole Nitrate + Diflucortolone Valerate

Warnings

**Application Duration:** Treatment must generally not exceed 2 weeks to prevent corticosteroid-induced skin atrophy; transition to a pure steroid-free antifungal cream if further therapy is required. **Contraindications:** Avoid use in patients with viral skin lesions (e.g., herpes simplex, varicella), cutaneous tuberculosis, or syphilitic skin lesions at the application site. **Ophthalmic Warning:** Not for ophthalmic use; application near the eyes or under occlusive dressings should be avoided due to the increased risk of systemic absorption and developing glaucoma.

Side Effects

**Common Local Reactions:** Transient skin irritation, burning, or a stinging sensation at the site of application. **Uncommon Localized Effects:** Erythema, localized dryness, or pruritus. **Prolonged Use Risks:** Skin thinning (atrophy), striae (stretch marks), telangiectasia, and potential hypothalamic-pituitary-adrenal (HPA) axis suppression if used over extensive body surfaces.