Poze 15mg (14 Tablet / Pack)

Poze 15mg is an oral antidiabetic medication used to enhance insulin sensitivity and improve glycemic control in patients with type 2 diabetes.

PKR 280.00

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Quantity:

SKU: POZE_15MG_14_TABLET_PACK

Category: Tablets & Capsules

Pioglitazone is an oral antidiabetic agent belonging to the thiazolidinedione class. It functions as a highly selective, potent agonist for the Peroxisome Proliferator-Activated Receptor-gamma (PPAR-gamma), a nuclear receptor predominantly located in insulin-sensitive metabolic tissues such as adipose tissue, skeletal muscle, and the liver. Activation of PPAR-gamma modulates the transcription of specific insulin-responsive genes involved in glucose control and lipid metabolism. This actions enhances peripheral insulin sensitivity, increases glucose uptake in muscles and fat, and suppresses hepatic gluconeogenesis without stimulating pancreatic insulin secretion.

Purpose

It is indicated as an adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes mellitus.

Ingredients

Pioglitazone

Warnings

**Heart Failure Risk:** Contraindicated in patients with established New York Heart Association (NYHA) Class III or IV heart failure, as it can induce fluid retention and exacerbate cardiac strain. **Bladder Cancer:** Avoid or use with extreme caution in individuals with active bladder cancer or a history of bladder malignancies. **Monitoring Requirements:** Periodic monitoring of liver function tests (LFTs) and clinical evaluation for signs of fluid volume overload (e.g., rapid weight gain, edema, dyspnea) are highly recommended.

Side Effects

**Metabolic & Fluid Dynamics:** Fluid retention, peripheral edema, weight gain, and mild reductions in hemoglobin/hematocrit. **Musculoskeletal:** Increased incidence of bone fractures (particularly in female patients) and localized myalgia. **Ophthalmic:** Rare occurrence or worsening of diabetic macular edema, resulting in blurred vision.